The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED50s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED50s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus[1].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Oxantel pamoate 是一种广泛使用的驱虫剂,有效针对Trichuris muris 和钩虫。- 高纯度,全球文献引用。Oxantel | Oxantel embonate | Parasite | Inhibitor | inhibitor | inhibitOxantel pamoate 是一种广泛使用的驱虫剂，有效针对Trichuris muris 和钩虫。- 高纯度，全球文献引用。Oxantel pamoate (Oxantel embonate)
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